CovidStanfordV1, Main, Exploration, bibRecord, 000503

Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke.

Identifieur interne : 000503 ( Main/Exploration ); précédent : 000502; suivant : 000504

Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke.

Auteurs : Mitchell S V. Elkind [États-Unis] ; Amelia K. Boehme [États-Unis] ; Craig J. Smith [Royaume-Uni] ; Andreas Meisel ; Marion S. Buckwalter

Source :

Stroke [ 1524-4628 ] ; 2020.

RBID : pubmed:32897811

Descripteurs français

KwdFr :
- Accident vasculaire cérébral (immunologie), Accident vasculaire cérébral (épidémiologie), Activation plaquettaire (MeSH), Agrégation plaquettaire (MeSH), Athérosclérose (immunologie), Athérosclérose (physiopathologie), Athérosclérose (épidémiologie), Bactériémie (immunologie), Bactériémie (physiopathologie), Bactériémie (épidémiologie), Betacoronavirus (MeSH), Endothélium (physiopathologie), Facteurs de risque (MeSH), Grippe humaine (immunologie), Grippe humaine (physiopathologie), Grippe humaine (épidémiologie), Humains (MeSH), Infection à virus varicelle-zona (immunologie), Infection à virus varicelle-zona (physiopathologie), Infection à virus varicelle-zona (épidémiologie), Infections à VIH (immunologie), Infections à VIH (physiopathologie), Infections à VIH (épidémiologie), Infections à coronavirus (immunologie), Infections à coronavirus (physiopathologie), Infections à coronavirus (épidémiologie), Infections à cytomégalovirus (immunologie), Infections à cytomégalovirus (physiopathologie), Infections à cytomégalovirus (épidémiologie), Inflammation (immunologie), Maladie chronique (MeSH), Pandémies (MeSH), Pneumopathie infectieuse (immunologie), Pneumopathie infectieuse (physiopathologie), Pneumopathie infectieuse (épidémiologie), Pneumopathie virale (immunologie), Pneumopathie virale (physiopathologie), Pneumopathie virale (épidémiologie), Pronostic (MeSH), Sujet immunodéprimé (immunologie), Thrombose (immunologie), Thrombose (épidémiologie), Troubles du rythme cardiaque (physiopathologie), Troubles du rythme cardiaque (épidémiologie).
MESH :

English descriptors

Abstract

Understanding the relationship between infection and stroke has taken on new urgency in the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a new concept, as several infections have long been recognized to contribute to stroke risk. The association of infection and stroke is also bidirectional. Although infection can lead to stroke, stroke also induces immune suppression which increases risk of infection. Apart from their short-term effects, emerging evidence suggests that poststroke immune changes may also adversely affect long-term cognitive outcomes in patients with stroke, increasing the risk of poststroke neurodegeneration and dementia. Infections at the time of stroke may also increase immune dysregulation after the stroke, further exacerbating the risk of cognitive decline. This review will cover the role of acute infections, including respiratory infections such as COVID-19, as a trigger for stroke; the role of infectious burden, or the cumulative number of infections throughout life, as a contributor to long-term risk of atherosclerotic disease and stroke; immune dysregulation after stroke and its effect on the risk of stroke-associated infection; and the impact of infection at the time of a stroke on the immune reaction to brain injury and subsequent long-term cognitive and functional outcomes. Finally, we will present a model to conceptualize the many relationships among chronic and acute infections and their short- and long-term neurological consequences. This model will suggest several directions for future research.

DOI: 10.1161/STROKEAHA.120.030429
PubMed: 32897811
PubMed Central: PMC7530056

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000342
to stream Main, to step Curation: 000342

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arrhythmias, Cardiac (epidemiology)</term>
<term>Arrhythmias, Cardiac (physiopathology)</term>
<term>Atherosclerosis (epidemiology)</term>
<term>Atherosclerosis (immunology)</term>
<term>Atherosclerosis (physiopathology)</term>
<term>Bacteremia (epidemiology)</term>
<term>Bacteremia (immunology)</term>
<term>Bacteremia (physiopathology)</term>
<term>Betacoronavirus (MeSH)</term>
<term>COVID-19 (MeSH)</term>
<term>Chronic Disease (MeSH)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (physiopathology)</term>
<term>Cytomegalovirus Infections (epidemiology)</term>
<term>Cytomegalovirus Infections (immunology)</term>
<term>Cytomegalovirus Infections (physiopathology)</term>
<term>Endothelium (physiopathology)</term>
<term>HIV Infections (epidemiology)</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (physiopathology)</term>
<term>Humans (MeSH)</term>
<term>Immunocompromised Host (immunology)</term>
<term>Infections (epidemiology)</term>
<term>Infections (immunology)</term>
<term>Infections (physiopathology)</term>
<term>Inflammation (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (physiopathology)</term>
<term>Pandemics (MeSH)</term>
<term>Platelet Activation (MeSH)</term>
<term>Platelet Aggregation (MeSH)</term>
<term>Pneumonia (epidemiology)</term>
<term>Pneumonia (immunology)</term>
<term>Pneumonia (physiopathology)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Prognosis (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Stroke (epidemiology)</term>
<term>Stroke (immunology)</term>
<term>Thrombosis (epidemiology)</term>
<term>Thrombosis (immunology)</term>
<term>Varicella Zoster Virus Infection (epidemiology)</term>
<term>Varicella Zoster Virus Infection (immunology)</term>
<term>Varicella Zoster Virus Infection (physiopathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (immunologie)</term>
<term>Accident vasculaire cérébral (épidémiologie)</term>
<term>Activation plaquettaire (MeSH)</term>
<term>Agrégation plaquettaire (MeSH)</term>
<term>Athérosclérose (immunologie)</term>
<term>Athérosclérose (physiopathologie)</term>
<term>Athérosclérose (épidémiologie)</term>
<term>Bactériémie (immunologie)</term>
<term>Bactériémie (physiopathologie)</term>
<term>Bactériémie (épidémiologie)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Endothélium (physiopathologie)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (physiopathologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Infection à virus varicelle-zona (immunologie)</term>
<term>Infection à virus varicelle-zona (physiopathologie)</term>
<term>Infection à virus varicelle-zona (épidémiologie)</term>
<term>Infections à VIH (immunologie)</term>
<term>Infections à VIH (physiopathologie)</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (physiopathologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Infections à cytomégalovirus (immunologie)</term>
<term>Infections à cytomégalovirus (physiopathologie)</term>
<term>Infections à cytomégalovirus (épidémiologie)</term>
<term>Inflammation (immunologie)</term>
<term>Maladie chronique (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie infectieuse (immunologie)</term>
<term>Pneumopathie infectieuse (physiopathologie)</term>
<term>Pneumopathie infectieuse (épidémiologie)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (physiopathologie)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Pronostic (MeSH)</term>
<term>Sujet immunodéprimé (immunologie)</term>
<term>Thrombose (immunologie)</term>
<term>Thrombose (épidémiologie)</term>
<term>Troubles du rythme cardiaque (physiopathologie)</term>
<term>Troubles du rythme cardiaque (épidémiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Arrhythmias, Cardiac</term>
<term>Atherosclerosis</term>
<term>Bacteremia</term>
<term>Coronavirus Infections</term>
<term>Cytomegalovirus Infections</term>
<term>HIV Infections</term>
<term>Infections</term>
<term>Influenza, Human</term>
<term>Pneumonia</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
<term>Thrombosis</term>
<term>Varicella Zoster Virus Infection</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Athérosclérose</term>
<term>Bactériémie</term>
<term>Grippe humaine</term>
<term>Infection à virus varicelle-zona</term>
<term>Infections à VIH</term>
<term>Infections à coronavirus</term>
<term>Infections à cytomégalovirus</term>
<term>Inflammation</term>
<term>Pneumopathie infectieuse</term>
<term>Pneumopathie virale</term>
<term>Sujet immunodéprimé</term>
<term>Thrombose</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Atherosclerosis</term>
<term>Bacteremia</term>
<term>Coronavirus Infections</term>
<term>Cytomegalovirus Infections</term>
<term>HIV Infections</term>
<term>Immunocompromised Host</term>
<term>Infections</term>
<term>Inflammation</term>
<term>Influenza, Human</term>
<term>Pneumonia</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
<term>Thrombosis</term>
<term>Varicella Zoster Virus Infection</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Athérosclérose</term>
<term>Bactériémie</term>
<term>Endothélium</term>
<term>Grippe humaine</term>
<term>Infection à virus varicelle-zona</term>
<term>Infections à VIH</term>
<term>Infections à coronavirus</term>
<term>Infections à cytomégalovirus</term>
<term>Pneumopathie infectieuse</term>
<term>Pneumopathie virale</term>
<term>Troubles du rythme cardiaque</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arrhythmias, Cardiac</term>
<term>Atherosclerosis</term>
<term>Bacteremia</term>
<term>Coronavirus Infections</term>
<term>Cytomegalovirus Infections</term>
<term>Endothelium</term>
<term>HIV Infections</term>
<term>Infections</term>
<term>Influenza, Human</term>
<term>Pneumonia</term>
<term>Pneumonia, Viral</term>
<term>Varicella Zoster Virus Infection</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Athérosclérose</term>
<term>Bactériémie</term>
<term>Grippe humaine</term>
<term>Infection à virus varicelle-zona</term>
<term>Infections à VIH</term>
<term>Infections à coronavirus</term>
<term>Infections à cytomégalovirus</term>
<term>Pneumopathie infectieuse</term>
<term>Pneumopathie virale</term>
<term>Thrombose</term>
<term>Troubles du rythme cardiaque</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term>
<term>COVID-19</term>
<term>Chronic Disease</term>
<term>Humans</term>
<term>Pandemics</term>
<term>Platelet Activation</term>
<term>Platelet Aggregation</term>
<term>Prognosis</term>
<term>Risk Factors</term>
<term>SARS-CoV-2</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation plaquettaire</term>
<term>Agrégation plaquettaire</term>
<term>Betacoronavirus</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Maladie chronique</term>
<term>Pandémies</term>
<term>Pronostic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Understanding the relationship between infection and stroke has taken on new urgency in the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a new concept, as several infections have long been recognized to contribute to stroke risk. The association of infection and stroke is also bidirectional. Although infection can lead to stroke, stroke also induces immune suppression which increases risk of infection. Apart from their short-term effects, emerging evidence suggests that poststroke immune changes may also adversely affect long-term cognitive outcomes in patients with stroke, increasing the risk of poststroke neurodegeneration and dementia. Infections at the time of stroke may also increase immune dysregulation after the stroke, further exacerbating the risk of cognitive decline. This review will cover the role of acute infections, including respiratory infections such as COVID-19, as a trigger for stroke; the role of infectious burden, or the cumulative number of infections throughout life, as a contributor to long-term risk of atherosclerotic disease and stroke; immune dysregulation after stroke and its effect on the risk of stroke-associated infection; and the impact of infection at the time of a stroke on the immune reaction to brain injury and subsequent long-term cognitive and functional outcomes. Finally, we will present a model to conceptualize the many relationships among chronic and acute infections and their short- and long-term neurological consequences. This model will suggest several directions for future research.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4628</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>51</Volume>
<Issue>10</Issue>
<PubDate><Year>2020</Year>
<Month>10</Month>
</PubDate>
</JournalIssue>
<Title>Stroke</Title>
<ISOAbbreviation>Stroke</ISOAbbreviation>
</Journal>
<ArticleTitle>Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke.</ArticleTitle>
<Pagination><MedlinePgn>3156-3168</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/STROKEAHA.120.030429</ELocationID>
<Abstract><AbstractText>Understanding the relationship between infection and stroke has taken on new urgency in the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a new concept, as several infections have long been recognized to contribute to stroke risk. The association of infection and stroke is also bidirectional. Although infection can lead to stroke, stroke also induces immune suppression which increases risk of infection. Apart from their short-term effects, emerging evidence suggests that poststroke immune changes may also adversely affect long-term cognitive outcomes in patients with stroke, increasing the risk of poststroke neurodegeneration and dementia. Infections at the time of stroke may also increase immune dysregulation after the stroke, further exacerbating the risk of cognitive decline. This review will cover the role of acute infections, including respiratory infections such as COVID-19, as a trigger for stroke; the role of infectious burden, or the cumulative number of infections throughout life, as a contributor to long-term risk of atherosclerotic disease and stroke; immune dysregulation after stroke and its effect on the risk of stroke-associated infection; and the impact of infection at the time of a stroke on the immune reaction to brain injury and subsequent long-term cognitive and functional outcomes. Finally, we will present a model to conceptualize the many relationships among chronic and acute infections and their short- and long-term neurological consequences. This model will suggest several directions for future research.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Elkind</LastName>
<ForeName>Mitchell S V</ForeName>
<Initials>MSV</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY. (M.S.V.E., A.K.B.).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY. (M.S.V.E., A.K.B.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boehme</LastName>
<ForeName>Amelia K</ForeName>
<Initials>AK</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY. (M.S.V.E., A.K.B.).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY. (M.S.V.E., A.K.B.).</Affiliation>
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<ArticleIdList><ArticleId IdType="pubmed">32897811</ArticleId>
<ArticleId IdType="doi">10.1161/STROKEAHA.120.030429</ArticleId>
<ArticleId IdType="pmc">PMC7530056</ArticleId>
<ArticleId IdType="mid">NIHMS1622115</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Mol Biol Rep. 2012 Jun;39(6):6537-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22311014</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neuroimmunol. 2018 Aug 15;321:144-149</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29576323</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2016 Nov;22(11):1277-1284</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27694934</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2010 Oct 27;304(16):1787-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20978258</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Atherosclerosis. 2016 Nov;254:117-123</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27728851</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2018 Jan 22;1:CD008530</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29355906</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2015 Nov;46(11):3232-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26451017</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2014 Sep 2;83(10):890-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25142897</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2015 Nov 7;386(10006):1835-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26343840</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cerebrovasc Dis. 2011;32(6):552-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22104620</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Neurol. 2015 Dec;22(12):1519-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24910016</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2012 Mar 1;188(5):2156-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22287710</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2019 Apr 1;129(4):1779-1784</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30720464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Stroke J. 2019 Dec;4(4):318-328</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31903430</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Neurosci. 2005 Oct;6(10):775-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16163382</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurol. 2019 Nov;266(11):2772-2779</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31359201</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroimmunomodulation. 2006;13(1):13-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16612133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2009 Aug;40(8):2849-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19443795</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2011 Oct;42(10):2763-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21799171</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Coll Cardiol. 2020 Jul 7;76(1):122-124</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32387623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroscience. 2009 Feb 6;158(3):1174-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18619524</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Chem. 2003 Oct;49(10):1752-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14500616</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>AIDS. 2014 Nov 13;28(17):2573-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25160935</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2009 Apr;40(4):1262-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19164783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2013 Mar 26;80(13):1209-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23530151</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2011 Oct 7;334(6052):101-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21921158</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Environ Res Public Health. 2014 Apr 02;11(4):3639-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24699027</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2015 Sep 29;85(13):1139-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26320196</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Neurol. 2020 Feb;33(1):30-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31789707</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neuroimmunol. 2016 Jun 15;295-296:68-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27235351</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Neurol. 2010 Jan;67(1):33-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19901154</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurol Neuroimmunol Neuroinflamm. 2020 Feb 25;7(3):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32098866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Neurol. 2015 Sep;271:46-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25959599</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain Behav Immun. 2017 Feb;60:142-150</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27742582</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2003 Sep 1;198(5):725-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12939340</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2017 Mar;48(3):574-580</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28196938</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Neurol. 2007 Feb;20(1):51-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17215689</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2009 Feb;15(2):192-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19169263</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2004 Dec 16;351(25):2611-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15602021</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2015 May;46(5):1180-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25765725</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2019 Apr 1;129(4):1536-1550</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30676325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Neurol. 2020 Jul 2;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32614385</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Neurol. 2017 Jan 19;8:6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28154551</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2016 Feb 23;133(8):732-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26813104</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2013 Aug;44(8):2212-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23723305</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Neurol. 2019 Mar;18(3):248-258</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30784556</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2019 Nov;50(11):3213-3219</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31526121</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2015 Aug;63(8):1540-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26289683</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Neurol Scand. 1977 Feb;55(2):145-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">842286</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Clin Transl Neurol. 2018 Mar 14;5(4):456-463</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29687022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2017 Apr 19;8:15051</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28422126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2020 Jul;51(7):2002-2011</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32432996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2015 May 12;84(19):1933-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25862803</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2011 Jul;42(7):1851-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21546476</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Thromb Haemost. 2020 Jul;18(7):1559-1561</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32302453</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2002 Nov;33(11):2581-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12411646</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2019 Aug;50(8):2216-2218</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31242826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2014 Nov 4;83(19):1705-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25280902</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Neuropathol. 2017 Dec;134(6):851-868</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28762187</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>F1000Res. 2019 Jul 10;8:1039</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31700615</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Heart Assoc. 2013 May 20;2(3):e000117</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23688675</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2015 May 20;35(20):7777-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25995466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2020 Apr;25(17):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32372757</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2011 Nov 23;306(20):2248-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22081378</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4983-4993</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32051245</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain. 2020 Jul 09;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32645151</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2007 Mar 27;115(12):1599-608</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17372179</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Neurol. 2012 Jun 05;8(7):401-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22664787</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2015 May 12;84(19):1948-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25695965</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Neurosci. 2019 Nov 26;13:1256</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31849581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2016 Jun;47(6):1612-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27165961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2015 Aug;46(8):2335-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26111886</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2006 Oct;37(10):2607-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16946159</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Aug 02;8(8):e69409</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23936327</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2014 May 27;82(21):1905-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24789867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Immunol. 2017 Dec 15;8:1673</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29326685</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Med. 2015 Dec 15;12(12):e1001919</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26671338</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Discov Med. 2015 May;19(106):381-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26105701</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2001 Jul 3;104(1):25-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11435333</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2020 Jun 1;130(6):2777-2788</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32391806</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Neurol. 2019 May 14;10:504</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31156537</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):801-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24558109</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Neurol. 1999 Sep;21(3):661-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10513695</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Coll Cardiol. 2006 Oct 3;48(7):1498-502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17010820</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain. 2019 Apr 1;142(4):978-991</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30860258</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurol Sci. 2016 Sep 15;368:77-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27538605</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2008 May 14;3(5):e2158</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18478129</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2018 Jun;49(6):1471-1478</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29695462</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2015 Feb 4;35(5):2133-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25653369</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Hist Neurosci. 1998 Dec;7(113 Pt 2):162-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11623840</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2016 May;22(5):516-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27019327</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Geriatr Psychiatry. 2014 May;29(5):497-505</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24123329</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2014 Jan;58(1):61-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24092802</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Med (Berl). 2009 Mar;87(3):273-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19050840</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cytokine. 2012 Jun;58(3):384-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22445501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2017 Oct;48(10):2875-2877</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28864597</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Infect Dis Rep. 2014 Jun;16(6):407</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24819870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2009 May;40(5):1849-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19265055</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Neurol. 2012 Jun;69(6):714-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22371852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Neurol. 2017 Apr 24;8:153</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28484421</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cereb Blood Flow Metab. 2017 Dec;37(12):3671-3682</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27733675</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neuroimmunol. 2016 Jun 15;295-296:9-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27235342</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Biosci (Landmark Ed). 2017 Jun 1;22:1867-1883</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28410150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2019 May;50(5):1046-1051</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30896327</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2014 Mar;45(3):794-800</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24523038</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurol Sci. 2011 Jan 15;300(1-2):97-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20934192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2009 Oct;40(10):3226-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19661470</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Physiol. 2014 Feb 19;5:56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24600402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>eNeuro. 2018 Nov 8;5(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30417081</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cerebrovasc Dis. 2008;25(1-2):50-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18033958</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stroke. 2018 Jul;49(7):1602-1609</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29915122</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Stroke J. 2016 Jun;1(2):76-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31008268</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2016 Jul 13;36(28):7428-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27413153</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1978 Jul 1;148(1):335-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">209124</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2015 Oct 27;85(17):1459-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26423434</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2013 Jan 24;121(4):679-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23160472</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Neurol. 2011 Sep 20;11:110</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21933425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transl Stroke Res. 2020 Jun;11(3):387-401</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31709500</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 May 14;382(20):e60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32343504</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroscience. 2009 Feb 6;158(3):1184-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18722511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2009 Aug;15(8):946-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19648929</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Neurol. 2020 Jun 1;77(6):683-690</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32275288</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2015 Jul 7;314(1):41-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26151265</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke.

Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke.

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